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Grenadier follows the travels of the extremely well-formed and busty Rushuna Tendo, an expert Senshi, and the samurai Yajiro Kojima, a mercenary swordsman. A Senshi or "Enlightened" is one who is skilled to some degree in the use of guns. The series begins with Yajiro and a small army of samurai launching a frontal assault against a fort in an attempt to free their lord, which was taken over by a group of gunners. The assault fails.

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