When Earth's population drastically increased, humanity led by the United Nations attempted to colonize Mars. During the colonization, they discovered two alien technologies: the Bacillus and the Crusnik nanomachines. The colonists installed the Bacillus in their bodies which transformed them into Methuselahs. They installed the Crusnik in the bodies of four test tube babies: Seth, Cain, Abel and Lilith whose enhanced bodies were the only ones able to survive the procedure.

Continuing wars on Earth eventually led to "Armageddon", the apocalyptic event that happened 900 years before the start of the story, and the colonists returned to Earth to help with rebuilding, but when the colonists returned to Earth, a war broke out between the Methuselahs and the humans who had remained on earth. Abel, Cain, and Seth took the Methuselah's side—while Lilith supported the Vatican, which guarded humanity. During the war, Cain went insane and killed Lilith. In grief, Abel took her body to the Vatican where she was buried. Abel remained at her side, weeping for her, for 900 years.

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